Preclinical Data Readout for MDL-001 - Direct-Acting, Broad-Spectrum Antiviral

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Preclinical Data Readout for MDL-001 - Direct-Acting, Broad-Spectrum Antiviral

Preclinical Data Readout for MDL-001 - Direct-Acting, Broad-Spectrum Antiviral

Get in Touch

Get in Touch

Publications

Scientific Transparency in

AI Drug Discovery

Explore the foundational science behind our platform and pipeline.

Oral Publications

Feb 22, 2026

Events

MDL-001, a Novel Oral Thumb-1 Polymerase Inhibitor, Shows Efficacy in HCV/HBV In Vitro and In Vivo

Dec 9, 2025

Events

Oral Thumb-1 polymerase inhibitor MDL-001 achieves preclinical HCV and HBV proof-of-concept, including HCV/HBV co-infection and equivalence to sofosbuvir

Nov 10, 2025

Events

MDL-001 as a Next-Generation HCV Thumb-1 Inhibitor with Clinical-Stage Safety

Oct 20, 2025

Events

MDL-001: A Broad-Spectrum Antiviral Targeting the Thumb-1 Domain of Viral Polymerases

Publications

Mar 18, 2026

Preprint

Model Medicines’ AmesNet™Achieves Best-in-Class Performance in AI-Driven Ames Mutagenicity Prediction

Mar 18, 2026

Preprint

Model Medicines’ AmesNet™Achieves Best-in-Class Performance in AI-Driven Ames Mutagenicity Prediction

Mar 18, 2026

Preprint

Model Medicines’ AmesNet™Achieves Best-in-Class Performance in AI-Driven Ames Mutagenicity Prediction

Mar 20, 2025

Preprint

AmesNet: A Deep Learning Model Enhancing Generalization in Ames Mutagenicity Prediction

Mar 20, 2025

Preprint

AmesNet: A Deep Learning Model Enhancing Generalization in Ames Mutagenicity Prediction

Mar 20, 2025

Preprint

AmesNet: A Deep Learning Model Enhancing Generalization in Ames Mutagenicity Prediction

Jan 26, 2025

Preprint

Demonstrating End-to-End Drug Discovery: GALILEO™ Unlocks Generative AI for Chemistry

Jan 26, 2025

Preprint

Demonstrating End-to-End Drug Discovery: GALILEO™ Unlocks Generative AI for Chemistry

Jan 26, 2025

Preprint

Demonstrating End-to-End Drug Discovery: GALILEO™ Unlocks Generative AI for Chemistry

Jan 14, 2025

Preprint

MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases

Jan 14, 2025

Preprint

MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases

Jan 14, 2025

Preprint

MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases

Apr 8, 2024

Preprint

Model Medicines Reveals Breakthrough AI Discovery: RdRp Thumb-1, A Universal RNA Antiviral Target, and MDL-001, a Potent Inhibitor

Apr 8, 2024

Preprint

Model Medicines Reveals Breakthrough AI Discovery: RdRp Thumb-1, A Universal RNA Antiviral Target, and MDL-001, a Potent Inhibitor

Apr 8, 2024

Preprint

Model Medicines Reveals Breakthrough AI Discovery: RdRp Thumb-1, A Universal RNA Antiviral Target, and MDL-001, a Potent Inhibitor

Mar 28, 2024

Preprint

Model Medicines Publishes Groundbreaking Preprint on AI-Driven Drug Discovery

Mar 28, 2024

Preprint

Model Medicines Publishes Groundbreaking Preprint on AI-Driven Drug Discovery

Mar 28, 2024

Preprint

Model Medicines Publishes Groundbreaking Preprint on AI-Driven Drug Discovery

White Papers

Sep 10, 2024

Paper

AI Hit Rates and Novelty

Sep 10, 2024

Paper

AI Hit Rates and Novelty

Sep 10, 2024

Paper

AI Hit Rates and Novelty

Mar 11, 2024

Paper

Dissimilar, Drug-Like, Novel Chemical Entities (DDL-NCEs); Using Multimodal Generative AI

Mar 11, 2024

Paper

Dissimilar, Drug-Like, Novel Chemical Entities (DDL-NCEs); Using Multimodal Generative AI

Mar 11, 2024

Paper

Dissimilar, Drug-Like, Novel Chemical Entities (DDL-NCEs); Using Multimodal Generative AI

Dec 19, 2023

Paper

Biochemistry's Hidden Matrix: Atomic Constellations

Dec 19, 2023

Paper

Biochemistry's Hidden Matrix: Atomic Constellations

Dec 19, 2023

Paper

Biochemistry's Hidden Matrix: Atomic Constellations

Sep 27, 2023

Paper

Vanity Metrics & Black Boxes ≠Therapeutics

Sep 27, 2023

Paper

Vanity Metrics & Black Boxes ≠Therapeutics

Sep 27, 2023

Paper

Vanity Metrics & Black Boxes ≠Therapeutics

Sep 12, 2023

Paper

Breaking the Data Dogma

Sep 12, 2023

Paper

Breaking the Data Dogma

Sep 12, 2023

Paper

Breaking the Data Dogma

Mar 20, 2023

Paper

Overcoming PAINS in AI Drug Discovery

Mar 20, 2023

Paper

Overcoming PAINS in AI Drug Discovery

Mar 20, 2023

Paper

Overcoming PAINS in AI Drug Discovery

Dec 13, 2022

Paper

The Tripledemic: AI-Drug Discovery and the Quest for a Pan-Antiviral Drug

Dec 13, 2022

Paper

The Tripledemic: AI-Drug Discovery and the Quest for a Pan-Antiviral Drug

Dec 13, 2022

Paper

The Tripledemic: AI-Drug Discovery and the Quest for a Pan-Antiviral Drug